AtroPenÒ Auto-Injector ATROPINE INJECTION
FOR USE IN NERVE AGENT AND INSECTICIDE POISONING ONLY
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CAUTION! PRIMARY PROTECTION AGAINST EXPOSURE TO CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING IS THE WEARING OF PROTECTIVE GARMENTS INCLUDING MASKS DESIGNED SPECIFICALLY FOR THIS USE.
INDIVIDUALS SHOULD NOT RELY SOLELY UPON ANTIDOTES SUCH AS ATROPINE AND PRALIDOXIME TO PROVIDE COMPLETE PROTECTION FROM CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING.
SEEK IMMEDIATE MEDICAL ATTENTION AFTER INJECTION WITH ATROPENÒ . |
A STERILE SOLUTION FOR INTRAMUSCULAR USE ONLY
DESCRIPTION
Each prefilled auto-injector provides a dose of the antidote atropine in a self-contained unit, specially designed for self or caregiver administration. Three strengths of AtroPenÒ are available; they are AtroPenÒ 0.5 mg, AtroPenÒ 1 mg, and AtroPenÒ 2 mg. When activated the AtroPenÒ 0.5 mg dispenses 0.42 mg atropine base (equivalent to 0.5 mg atropine sulfate), the AtroPenÒ 1 mg dispenses 0.84 mg atropine base (equivalent to 1 mg atropine sulfate), and the AtroPenÒ 2 mg dispenses 1.67 mg atropine base (equivalent to 2 mg atropine sulfate).
Each AtroPenÒ delivers atropine in 0.7 mL of sterile pyrogen-free solution containing glycerin, phenol, citrate buffer and water for injection. The pH range is 4.0¨C5.0.
After the AtroPenÒ Auto-injector has been activated, the empty container should be disposed of properly (see DOSAGE AND ADMINISTRATION). It cannot be refilled, nor can the protruding needle be retracted.
Atropine, an anticholinergic agent (muscarinic antagonist), occurs as white crystals, usually needle-like, or as a white, crystalline powder. It is highly soluble in water with a molecular weight of 289.38. Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Chemically, atropine is designated as 1 H,5 H-Tropan-3 ¨Col (¡À) -tropate. Its empirical formula is C17H23NO3
